Novel Pd-N-Heterocyclic Carbene Complexes: Design, Synthesis and Applyment in Buchwald-Hartwig Cross Coupling Reaction

Abstract

N-Heterocyclic carbene (NHC) palladium complexes with different imine ligands have been developed and applied in Buchwald-Hartwig cross coupling reaction. The structure of imine ligand would influence the catalytic activity apparently. Especially, the imine ligand with electron withdrawing group performed best. Low to 0.5 mol% catalyst loading could realize effective Buchwald-Hartwig cross coupling reaction between various aryl chlorides and amines.