Electrochemical biosensors as a tool for the investigation of DNA structure, damage and interaction with other molecules

Abstract

In recent years, a great progress was achieved in the development of electrochemical sensors for DNA sequences, hybridization and damage. Nowadays, electrochemical methods are able to detect DNA at nanomolar concentration. In addition, these methods are suitable for studding both covalent and non-covalent binding interactions between DNA and different small molecules, e.g. drugs or potentially mutagenic agents. This suggests that electrochemical biosensors might become important tools in medical research. The aim of this review is to draw attention to the applicability of different electrochemical techniques for studying interactions between DNA with other molecules, and in the design of new sensitive and selective biosensors.