A genetic basis for human susceptibility to West Nile virus

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Abstract

West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5Δ32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases. © 2006 Elsevier Ltd. All rights reserved.

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Diamond, M. S., & Klein, R. S. (2006, July). A genetic basis for human susceptibility to West Nile virus. Trends in Microbiology. https://doi.org/10.1016/j.tim.2006.05.004

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