Evaluation of teratogenicity-Indian medicine formulations nilavembu kudineer and mathulai manapagu using zebrafish model

Abstract

A teratogen is a drug or other substance capable of damaging the DNA and interfering with the development of an embryo and it may lead to birth defects or developmental malformations. The present study is carried out to evaluate the Indian Medicines Nilavembu Kudineer and Madulai Manapagu. In Siddha system, Nilavembu Kudineer is given to treat Dengue fever whereas Madulai Manapagu is to improve the hemoglobin content and the management of hormonal imbalance in women. The results exemplified the overall percentage mortality, hatchability, and deformities were observed as low in Madulai Manapagu than Nilavembu Kudineer. The teratogenic index of Nilavembu Kudineer is higher than 1 (1.33), whereas LC50 EC50 values were observed as 80 μg/ ml and 60 μg/ml respectively. Hence, Nilavembu Kudineer is considered as teratogenic when compared to Madulai Manapagu.