Multidrug-Resistant Organisms and Determinant Factors in Sepsis Patients

Abstract

Background and Aim: Antibiotic resistance has a major contribution to human health. As reported in 2009, Indonesia ranked 8th out of 27 countries with the highest MDRO rate in the world. To determine the risk factors of infection due to MDROs at Dr.M.Djamil General Hospital in sepsis patients, it is necessary to identify the factors that cause MDROs; thus, effective prevention and control methods can be planned. Materials and Methods: This was a cross-sectional study conducted on 101 patients with 124 isolates diagnosed with sepsis who were treated at Dr.M.Djamil General Hospital. The characteristics and factors associated with MDROs in sepsis patients were recorded for each subject. Then, a bacterial culture examination was performed with blood culture and other cultures depending on the focus of infection. A descriptive analysis was conducted to analyze the frequency distribution of each research variable. Bivariate analysis was performed to determine the relationship between each variable and infection due to MDROs in sepsis patients, and multivariate logistic regression analysis was performed to find the most dominant variable. Results & Conclusion: History of antibiotic use (P<0.05) and urinary catheter use (P<0.05) had a significant correlation with infection due to MDROs, and urinary catheter use and history of antibiotic use were the strongest risk factors associated with infection due to MDROs in sepsis patients admitted to Dr.M.Djamil General Hospital. Antibiotics should be used wisely and rationally in managing infectious patients, and the use of urinary catheters should be done more selectively for inpatients to prevent the development of MDROs as a cause of infection.