Sestrins at the crossroad between stress and aging

Abstract

Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target ofrapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide criticalfeedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionaryconstraints. © Hee Lee et al.