CTX-M β-lactamase production and virulence of Escherichia coli K1

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Abstract

We report a patient with neonatal meningitis caused by a CTX-M-1-producing Escherichia coli K1 strain. The influence of CTX-M production on virulence was investigated in cell culture and a newborn mouse model of meningitis. CTX-M production had no influence on virulence but was a major factor in clinical outcome.

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Dubois, D., Prasadarao, N. V., Mittal, R., Bret, L., Roujou-Gris, M., & Bonnet, R. (2009). CTX-M β-lactamase production and virulence of Escherichia coli K1. Emerging Infectious Diseases, 15(12), 1988–1990. https://doi.org/10.3201/eid1512.090928

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