Identification of mutaprodenafil in a dietary supplement and its subsequent synthesis

Abstract

We isolated a new illegal sildenafil analogue named mutaprodenafil from a dietary supplement for erectile dysfunction (ED) and proposed that it is an aildenafil derivative containing an imidazole moiety. We subsequently synthesized mutaprodenafil from a thioaildenafil and authenticated its structure. © 2011 Pharmaceutical Society of Japan.