Synthesis and Anticancer Activity of Novel Thiazolo-Coumarin Derivatives

Abstract

As a starting point for creating new inhibitor scaffolds, a molecular hybridization approach was applied in designing the novel molecules using coumarin-thiazole hybrids as mPGES-1 enzyme inhibitors. Thus, in present work, the novel thiazolo coumarin derivatives (8-35) were synthesized and characterized by 1H NMR, IR and ESI-MS spectra. All the synthesized molecules (8-35) were also investigated for their anticancer activity on MCF-7 (breast cancer), caco-2 (colon cancer), HeLa (Cervix cancer) cell lines. Studies revealed that compounds (8-14) and (22-28) showed inhibition (IC50) at different concentrations of 12.5, 50, 100 µg/mL and more than 100 µg/mL.