Mode of action of vinca alkaloids against cancer using Insilco analysis technique

Abstract

Plants have been known for their medicinal properties across the world for a long time. In the field of medicine, medicinal plants have played a critical role. Catharanthus roseus is one such plant with enormous medical significance and potential. C.roesus, often known as Madagascar periwinkle, is a major drug-producing plant. More than 200 alkaloids are found in all parts of the plant, including the leaf, root, shoot, and stem, and are used to treat a variety of diseases. Vinca alkaloids are also effective cancer fighters. To see the mode of action of vinca alkaloids against cancer, 3D structure of Tubulin alpha-beta dimer was obtained from the database, The vinca alkaloids were obtained from Zinc database. In recent years, protein-ligand docking has become a powerful tool for drug development. The final PDB file of Tubulin alpha-beta dimer (PDB Id: 1TUB) and alkaloids were directly fed into an online docking server, SwissDock (http://www.swissdock.ch/docking). In this research we will find out that how Vinca alkaloids are commonly used in combination chemotherapy regimens for medicinal treatments. The vinca alkaloids have cytotoxic properties that can halt cell division and cause cell death.