Electroanalytical determination of metronidazole in tablet dosage form

Abstract

In this study, the electrochemical reduction and determination of metronidazole were easily realized in Britton-Robinson buffer (pH 4.01) using an UTGE by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. In this acidic medium, one irreversible and a sharp cathodic peak were observed. A linear calibration curve for DPV analysis was constructed in the metronidazole concentration range 3×10-6-9×10 -5 mol L-1. The limit of detection (LOD) and limit of quantification (LOQ) were 1.42×10-7 and 4.76×10 -7 mol L-1 respectively.