SPEED: Single-point evaluation of the evolution dimension

Abstract

Two-dimensional NMR spectroscopy can be speeded up by orders of magnitude by severely restricting the number of sampling operations in the evolution dimension-we demonstrate that just a single measurement may suffice. The frequencies evolving in the indirect dimension (t1) are deduced from the amplitudes of the signals acquired in the direct dimension (t2). Prior measurements of the one-dimensional spectra are required. Results are presented for the two-dimensional 13C-HSQC spectrum of 2-ethylindanone recorded at a single fixed setting of the evolution time, demonstrating a speed advantage of 120. The method can be extended to multidimensional spectra, with correspondingly greater gains in speed. Copyright © 2007 John Wiley & Sons, Ltd.