Utilidad diagnóstica del volumen plaquetario medio en embarazadas con preeclampsia.

Abstract

OBJECTIVE: To establish the diagnostic utility of the mean platelet volume in pregnant women with preeclampsia. METHODS: Case-control study was done at Hospital Central “Dr. Urquinaona”, Maracaibo, Venezuela. A total of 180 patients were selected. Ninety preeclamptic patients were selected as the study group (group A) and 90 healthy normotensive pregnant women with the same age and body mass index as the study group were selected as controls (group B). Blood samples were extracted from all patients before labor and immediately after diagnosis in group A to determine mean platelet volume. General characteristics, mean platelet volume values and diagnostic efficacy were determined. RESULTS: There was a statistically significant difference in mean platelet volume values between patients in study group (group A: 10.35 +/- 1.11 fL) and patients in control group (group B: 9.54 +/- 0.96 fL; p < 0.001). There was no significant correlation with systolic and diastolic blood pressure values (p = ns). A cutoff value of 10.3 fL had an area under the curve of 0.71, sensitivity 53.3%, specificity 63.1%, positive predictive value 63.2% and negative predictive value 59.6%, with diagnostic accuracy of 61.1%. CONCLUSION: Mean platelet volume values are not useful for discriminating the diagnosis of preeclampsia in pregnant women, although the preeclamptic values were significantly higher when compared with healthy normotensive pregnant women.