Urokinase gene 3′-UTR T/C polymorphism is not associated with bladder cancer

Abstract

Urokinase degrades basement proteins and is hypothesized to play a role in cancer progression. We investigated the hypothesis of C/T polymorphism in the 3′-untranslated region (3′-UTR) of the urokinase gene being associated with the development of bladder cancer. Such an association seems unlikely, since the genotype distributions in 114 bladder cancer patients did not differ from those of 105 controls. Copyright by the Brazilian Society of Genetics.