Recent advances in photo-crosslinkable hydrogels for biomedical applications

Abstract

Photo-crosslinkable hydrogels have recently attracted significant scientific interest. Their properties can be manipulated in a spatiotemporal manner through exposure to light to achieve the desirable functionality for various biomedical applications. This review article discusses the recent advances of the most common photocrosslinkable hydrogels, including poly(ethylene glycol) diacrylate (PEGDA), gelatin methacryloyl (GelMA) and methacrylated hyaluronic acid (MeHA), for various biomedical applications. We first highlight the advantages of photopolymerization and discuss diverse photosensitive systems used for the synthesis of photo-crosslinkable hydrogels. We then introduce their synthesis methods and review their latest state of development in biomedical applications, including tissue engineering and regenerative medicine, drug delivery, cancer therapies and biosensing. Lastly, the existing challenges and future perspectives of engineering photocrosslinkable hydrogels for biomedical applications are briefly discussed.