Thymol and its derivatives as antimicrobial agents

Abstract

From the seeds of Carum copticum thymol (1) was isolated as the major component and ten derivatives (2-11) were prepared by reacting it with different acid chlorides in a single step. They were evaluated for antimicrobial activity against twelve bacterial strains and nine fungal strains using disc diffusion and broth dilution assays. Derivative 9 was found to be most active against both bacterial and fungal strains.