Effect of interferon-γ in experimental Cryptosporidium parvum infection

Abstract

The activity of recombinant murine interferon-γ (IFN-γ) against infection by Cryptosporidium parvum was evaluated in immunosuppressed rats. Daily intraperitoneal doses of at least 125,000 U/kg significantly (P < .05) inhibited colonization of the biliary tract. When administered for 11 days to rats with established C. parvum infection, IFN-γ significantly (P < .05) reduced the number of parasites in the small intestine, but this treatment was ineffective against infection of the biliary tract and large intestine. Although the parasite loads in the common bile duct and large intestine were not significantly reduced, there were fewer cases of infection among the treated rats than in the control group. The data suggest that treatment with IFN-γ may limit cryptosporidiosis of the small intestine.