Acetophenones isolated from acronychia pedunculata and their anti-proliferative activities

Abstract

Study of the chemical constituents of Acronychia pedunculata (L.) Miq. (Rutaceae) stems collected in Taiwan led to the isolation and identification of eight known and three new acetophenones, named acrophenone A (1), B (2), and C (3). Of them, acrovestone (5), acropyrone (6) and acrovestenol (7) , which are dimer compounds, strikingly inhibited the proliferation of human leukemia cell lines.