Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates

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Abstract

The Ru(II)-catalyzed amidation of 2-Arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described previously, due to the formation of a series of side products, which were readily identified using direct infusion electrospray mass spectrometry and high-performance liquid chromatography-mass spectrometry.

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McKay, A. I., Altalhi, W. A. O., McInnes, L. E., Czyz, M. L., Canty, A. J., Donnelly, P. S., & O’Hair, R. A. J. (2020). Identification of the Side Products That Diminish the Yields of the Monoamidated Product in Metal-Catalyzed C-H Amidation of 2-Phenylpyridine with Arylisocyanates. Journal of Organic Chemistry, 85(4), 2680–2687. https://doi.org/10.1021/acs.joc.9b02831

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