Label-Free MIP Sensors for Protein Biomarkers

Abstract

Molecularly imprinted polymers (MIPs) have been prepared mostly for low-molecular-weight biomarkers and drugs but also for a spectrum of proteins. As compared with antibodies, MIPs have higher chemical and thermal stability, and they can be regenerated for repeated measurements. Electrochemical methods dominate the read-out of MIP sensors. Many protein MIPs have been tested in artificial urine or spiked semi-synthetic plasma, and point-of-care detection of marker proteins e.g. for cardiac, cancer, Alzheimer’s disease or virus infections is the prospective aim.