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MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

Molecular Cell (2019) 74(3) 571-583.e8
DOI: 10.1016/j.molcel.2019.02.014
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Abstract

Leimbacher et al. reveal that two DNA damage-response mediator proteins, MDC1 and TOPBP1, form a complex required for maintaining chromosome stability when DNA double-strand breaks occur during mitosis, possibly by tethering broken chromosomes together until DNA-repair pathways are reactivated in the following G1 phase.

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APA

Leimbacher, P. A., Jones, S. E., Shorrocks, A. M. K., de Marco Zompit, M., Day, M., Blaauwendraad, J., … Stucki, M. (2019). MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis. Molecular Cell, 74(3), 571-583.e8. https://doi.org/10.1016/j.molcel.2019.02.014

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