Approaches for synthesis and chemical modification of non-condensed heterocyclic systems based on 1,3,4-oxadiazolering and their biological activity: A review

Abstract

1,3,4-Oxadiazole scaffold is one of the most important heterocyclic fragments, which is considered as a perspective building block for drug discovery. Substituted 1,3,4-oxadiazoles had been reported to display a diverse range of pharmacological activities including anticancer, anti-inflammatory, antitubercular, antibacterial, antiviral, antifungal, insecticidal, antioxidant, and analgesic activities. Moreover, the 1,3,4-oxadiazole core is a structural component of approved antiretroviral (Raltegravir), anticancer (Zibotentan), and antihypertensive (Tiodazosin and Nesapidil) drugs. In the present review, we summarized the literature data about the main approaches for obtaining possible directions of structural modification and pharmacological activity of noncondensed heterocyclic systems based on the 1,3,4-oxadiazole ring as promising objects for modern bioorganic and medicinal chemistry.