Deprotection of the indole (Nind)-formyl (for) group on tryptophan employing a new reagent, N,N′-dimethylethylendiamine (DMEDA) in an aqueous solution

Abstract

The deprotection of the indole (N ind)-formyl (For) group on Trp was achieved in a 95% yield using N,N′-di- methylethylendiamine (DMEDA) (1.5, 2.0, 3.0 eq) in water at room temperature. A new reagent was successfully applied to the deprotection of a model peptide, H-Phe-Trp(Nind-For)- Lys-Tyr-OH, to give H-Phe-Trp-Lys-Tyr-OH in a 91% yield. ©2009 Pharmaceutical Society of Japan.