The combination of inhibition of RNA degradation and comparative genomic scanning is a powerful new method for detecting gene disruptions. The utility of the method is well-illustrated by a series of observations linking the ephrin receptor EPHB2 to prostate cancer.
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Mercola, D., & Welsh, J. (2004, September). From mRNA to tumor suppressor. Nature Genetics. https://doi.org/10.1038/ng0904-937