Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: Beginning to end

Abstract

The mechanisms that maintain the stability of chromosome ends have broad impact on genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere studies. Many fundamental concepts of telomere and telomerase function were first established in yeast and then extended to other organisms. We present a comprehensive review of yeast telomere biology that covers capping, replication, recombination, and transcription. We think of it as yeast telomeres-soup to nuts. © 2012 by the Genetics Society of America.