Antinociceptive effect of crude extract, fractions and three alkaloids obtained from fruits of Piper tuberculatum

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Abstract

This study investigated the possible antinociceptive effect of the crude extract, fractions and pure compounds (three alkaloids) obtained from fruits of Piper tuberculatum JACQ. (Piperaceae) in acetic acid-induced visceral pain in mice. Oral administration of crude extract and fractions (CH2Cl 2, EtOAc, methanol and hexane) (3-300 mg kg-1) caused a dose-related and significant inhibition of the acetic acid-induced visceral nociceptive response. The crude extract, dichloromethane (CH2Cl 2) and ethyl acetate (EtOAc) fractions were more potent than methanol and hexane fractions. The isolated alkaloids dihydro-piplartine, piplartine and 3,4,5-trimethoxydihydrocinnamic acid (0.0001-30 mg kg-1) exhibited significant and dose-related antinociceptive effects against acetic acid-induced visceral pain. The results show, for the first time, that crude extract, fractions and pure compounds obtained from P. tuberculatum produce marked antinociception against the acetic acid-induced visceral nociceptive response, supporting the ethnomedical use of P. tuberculatum. © 2009 Pharmaceutical Society of Japan.

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Rodrigues, R. V., Lanznaster, D., Longhi Balbinot, D. T., Gadotti, V. D. M., Facundo, V. A., & Santos, A. R. S. (2009). Antinociceptive effect of crude extract, fractions and three alkaloids obtained from fruits of Piper tuberculatum. Biological and Pharmaceutical Bulletin, 32(10), 1809–1812. https://doi.org/10.1248/bpb.32.1809

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