Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients

  • Costa-Carvalho B
  • Martinez R
  • Dias A
  • et al.
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Abstract

The majority of children with Down syndrome (DS) tend to have frequentbacterial infections including recurrent respiratory infections. Ourobjective was to evaluate the production of antibodies to pneumococcalpolysaccharide antigens after active immunization in DS subjects. IgGantibodies to pneurnococcal serotypes (1, 3, 613, 9V, and 14) weremeasured before and 6 weeks after immunization with a 23-valentpneumococcal vaccine (Pneumo23 (R), Pasteur-Merrieux) in 6- to13-year-old DS children (N = 17) and in aged-matched normal controls (N= 30). An adequate response was defined as a 4-fold increase overbaseline or a post-immunization level of specific pneumococcal serotypeantibody >= 1.3 mu g/mL. After immunization, all DS children had anincrease in post-immunization levels against all serotypes analyzed. A4-fold or more increase was observed in all DS children concerningserotypes 1 and 14, in 90% of subjects for serotypes 3 and 9V, and in65% for serotype 6B. Regarding this increase, 8 of the 17 DS childrenhad an adequate response to all serotypes analyzed, 8/17 patients to 4serotypes and 1/17 to 3 serotypes. However, when we comparedpost-immunization levels between DS children and controls, we observedlower levels in the former group (P < 0.05) for all serotypes exceptserotype 3. We conclude that pneumococcal polysaccharide immunizationcould be beneficial for these DS children.

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Costa-Carvalho, B. T., Martinez, R. M. A., Dias, A. T. N., Kubo, C. A., Barros-Nunes, P., Leiva, L., … Sorensen, R. U. (2006). Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients. Brazilian Journal of Medical and Biological Research, 39(12), 1587–1592. https://doi.org/10.1590/s0100-879x2006005000047

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