Chlorocardicin, a monocyclic β-lactam from a streptomyces sp. i. discovery, production and biological activities

Abstract

Chlorocardicin is a new monocyclic β-lactam, produced by a Streptomyces sp. It is structurally related to nocardicin A but differs in having a m-chloro substituent on the p-hydroxyphenylglycine unit. The biological activity of chlorocardicin wassimilar to nocardicin A but the former showed less antagonism in complex media. Moderate in vitro activity was observed against Enterobacteriaceae and Pseudomonas aeruginosa. Chlorocardicin showed low activity against Staphylococcus aureus whereas nocardicin A was inactive. Both compounds were shown to be strongly potentiated by antibiotics that inhibit peptidoglycan biosynthesis and were antagonized by selected L-and D-amino acids. © 1985, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.