Branch selective Murai-type alkene hydroarylation reactions

Abstract

There is significant interest in the development of CC bondforming methodologies that directly access challenging benzylic stereocenters. Predominantly, efforts have been focused on the development of enantiospecific or enantioselective crosscoupling methodologies. An alternate and conceptually ideal approach involves the development of branch-selective and enantioselective Murai-type alkene hydroarylations. Recent progress towards this broad, yet challenging goal is highlighted.