Multicomponent synthesis in water of 7-unsubstituted 4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidines and their antimicrobial and antifungal activity

Abstract

Simple, efficient and eco-friendly method for preparation of 7-unsubstituted 4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidines was elaborated, which presumes the three-component reaction of 3-amino-1,2,4-triazole with paraformaldehyde and different 1,3-dicarbonyl compounds in hot-water by either conventional heating or microwave irradiation without any catalyst. The target compounds showed antimicrobial and antifungal activity.