ROLE OF ACTIVATED CHARCOAL IN LIMITING THE PROGRESSION OF CHRONIC KIDNEY DISEASE IN ALBINO RATS

Abstract

Background: Chronic kidney disease (CKD) is characterized by impaired kidney function, progressive kidney damage, unbalanced gut microbiota and disrupted intestinal mucosal barrier function. The damaged intestinal barrier functions mediated mostly by urea, allows influx of toxic products such as indoxyl sulphate that cause systemic inflammation. Activated charcoal is a universal antidote for the majority of poisons. Activated charcoal was suggested as a supplementary treatment for patients with CKD to remove waste products such as urea, indoxyl sulphate and other toxins .