Synthesis and Biological evaluation of Novel Nicotinonitrile derivatives derived from N-Substituted Coumarinyl Chalcones

Abstract

This work included synthesis of several new pyridine derivatives (3a-c) by cyclization of Coumarinyl Chalcones (2a-c) with malononitrile in presence of ammonium acetate. Prepared compounds were diagnosed using Melting point, TLC, FT-IR spectroscopy and 1H-NMR. The synthesized pyridines (3a-c) were screnned for their antibacterial and antifungal activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella sp., and Candida albicans. Respectively by diffusion method compounds 3a, 3b and 3c showed good antibacterial activity and by comparison with the medicine Ampicillin. Compounds 3a, 3b and 3c showed moderate antifungal activity compared to the standard drug fluconazole.