The RhoD to centrosomal duplication

Abstract

The main functional roles attributed to the centrosome, the major micro-tubule organizing center (MTOC) of metazoans, are related to cell locomotion, sensory perception and division. The role of vesicular traffcking in the regulation of the centrosome cycle has been largely unexplored. Recently, however, several studies have indicated the involvement of molecules and/or complexes of the traf-fcking routes in centrosome positioning, duplication and regulation. Functional screens have revealed communication between the outer nuclear envelope, the Golgi apparatus, the endosomal recycling compartment and centrosomes, while other studies underline the involvement of the ESCRT complex proteins in cen-trosome function. In this commentary, we discuss our recent study, which shows the involvement of an endosomal Rho protein, namely RhoD, in centrosome duplication and possible links between the centrosome's structural and functional integrity to vesicular traffcking. © 2013 Landes Bioscience.