Abstract
This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood–retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel approach to modulate ocular inflammatory processes.
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Ebneter, A., Kokona, D., Jovanovic, J., & Zinkernagel, M. S. (2017, March 1). Dramatic effect of oral CSF-1R kinase inhibitor on retinal microglia revealed by in vivo scanning laser ophthalmoscopy. Translational Vision Science and Technology. Association for Research in Vision and Ophthalmology Inc. https://doi.org/10.1167/tvst.6.2.10
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