Inflammatory cytokines in children and adolescents with depressive disorders: A systematic review and meta-Analysis

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Abstract

Objective: Meta-Analytic evidence shows alterations of peripheral inflammatory cytokines in adults with depressive disorders. By contrast, no evidence synthesis on alterations of peripheral inflammatory cytokines in children/adolescents with depressive disorders is available to date. To fill this gap, we conducted a systematic review and meta-Analysis of case-control studies comparing serum cytokine levels in children/adolescents with depressive disorders and healthy controls. Methods: Based on a preregistered protocol (PROSPERO-CRD42018095418), we searched PubMed, Ovid, and Web of Knowledge from inception through July 21, 2018, with no language restrictions, and contacted study authors for unpublished data/information. Random-effects model was used to compute effect size for each cytokine. The Newcastle-Ottawa Scale was used to asses study bias. Results: From a pool of 4231 nonduplicate, potentially relevant references, 8 studies were retained for the qualitative synthesis and 5 for the meta-Analysis. TNF-α was higher in participants with depressive disorders versus controls, falling short of statistical significance. Conclusions: Overall, due to the small number of studies, in contrast to the literature in adults, further evidence is needed to confirm possible inflammatory alterations associated with depression in youth.

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APA

D’Acunto, G., Nageye, F., Zhang, J., Masi, G., & Cortese, S. (2019, June 1). Inflammatory cytokines in children and adolescents with depressive disorders: A systematic review and meta-Analysis. Journal of Child and Adolescent Psychopharmacology. Mary Ann Liebert Inc. https://doi.org/10.1089/cap.2019.0015

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