EP 4 : A new piece in the fibrotic puzzle

Abstract

Most progressive and severe acute kidney diseases lead to renal fibrosis, for which we still lack effective treatment options. Prostaglandin E 2 (PGE 2 ) is one of the most abundant prostanoids, exerting its pleiotropic functions via four receptors, EP 1 through EP 4 . Recent studies indicate that the PGE 2 -EP 4 pathway is a potent endogenous renoprotective system that limits renal fibrosis by acting on multiple cellular targets. © 2012 International Society of Nephrology.