Hematological Parameters in Dengue: The Serological Angle A Study

Abstract

Aim : Dengue occurs as epidemics in India. As there is no specific antiviral therapy, early diagnosis in resource poor settings helps reduce mortality. Our study is to analyse the utility of hematology parameters in association with serology patterns in dengue. Materials and Methods : A total of 132 serologically proven dengue cases over a month period in November 2016 along with relevant  hematological data (obtained by automated hematology analyser and peripheral smears) were analyzed. Results : The age range was 5months to 65years with male preponderance.Serology patterns showed NS1 antigen positivity in 29% and IgG positivity in 25%. Rise in hematocrit was noted in 38% of  NS1 with antibody as against 28% of NS1 only cases, indicating it was a later event. Leucopenia was prominent (87%) in NS1 (alone and NS1 with antibody) indicating it was an early marker of dengue. Leucocytosis (83%) and neutrophilia (50%) were noted in antibody patterns indicating that they could be late events ( and ? recovery parameters). Thrombocytopenia was noted in 43%of antibody pattern as against 21% of NS1 pattern, indicating it was a late event. Conclusion : In resource limited rural setups in India, haematological parameters may have utility as early markers of dengue and in association with serology aid in early diagnosis and management. Keywords - Dengue, NS1 antigen, Antibody, Blood counts.