Biofunctionalization of metallic materials: Creation of biosis-abiosis intelligent interface

Abstract

Osseointegration, the first concept of biosis-abiosis intelligent interface, is primarily explained, and researches on the elucidation of osseointegration mechanism and titanium-tissue interface observation are reviewed to understand a concept to create biosis-abiosis intelligent interface. In addition, current status of surface treatment of metallic materials is reviewed. In particular, a gap between research level progress and commercialization in surface treatments is focused. Mechanical property, durability, and manufacturing process of surface layer formed on titanium by surface treatment, are significant to commercialize the treatment, while most of researches focuses only evaluation of biocompatibility and biofunction.