CD8 cell noncytotoxic antiviral activity in human immunodeficiency virus-infected and -uninfected children

Abstract

CD8 cells from human immunodeficiency virus (HIV)-infected adults and children can show cytotoxic as well as noncytotoxic activity against viral replication. The noncytotoxic anti-HIV response, measured by suppression of acute vital infection of CD4 cells, has also been observed in uninfected adults who have a history of exposure to HIV. This CD8 cell antiviral activity was found to be detectable as well in ~50% of uninfected children born of infected mothers. The findings could reflect a protective response of the children to HIV after being exposed to the virus.