Controlled release of copper from an intrauterine device using a biodegradable polymer

Abstract

Background The adverse effects of copper intrauterine devices (IUDs) such as abnormal bleeding, pain and cramps may be due in part to the burst release of copper ions during the first few months of usage. This study focuses on controlling the initial burst release of copper ions. Study design This study evaluated in vitro release rates of copper for a period of 1 year from standard CuT380 IUDs (n= 6) and from CuT380 IUDs coated with poly(dl-lactide-co-glycolide) (PLGA) films (n= 6). This study characterized the coated device for its morphological changes during degradation of film by scanning electron microscopy (SEM). Results CuT380 IUDs coated with PLGA film with a thickness of 0.10±0.02 mm showed a reduced initial copper release (40-80 mcg/day) compared with uncoated CuT380 IUDs (150-200 mcg/day). Statistically significant (p