Synthesis and Evaluation of Anti-inflammatory Activity of Some Cinnoline Derivatives-4(-2-amino-thiophene) Cinnoline-3-Carboxamide

Abstract

A prolonged increase in pro-inflammatory cytokines, TNF-α and IL-6 occurs in inflammatory diseases. Although cinnoline belongs to a family of fairly well known heterocycles, the interest in the study of its derivatives continues. Cinnoline compounds demonstrate interesting bioactivity and many research papers have discussed the biological property, structure-activity relationship, and applications in medicinal science. A new series of substituted Cinnoline derivatives condensed with Thiophene moieties (12a-j) were synthesized and their anti-inflammatory was evaluated. The anti-inflammatory activity was assessed by rat paw edema method. The pharmacological screening showed that many of these obtained compounds have significant anti-inflammatory activity, comparable to the standard drug (phenylbutazone). The compound 12DSDi produces maximum anti-inflammatory activity compared to other tested compound.