CyberKnife with tumor tracking: An effective treatment for high-risk surgical patients with single peripheral lung metastases

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Abstract

Standard treatment for operable patients with single peripheral lung metastases is metastasectomy. We report mature CyberKnife outcomes for high-risk surgical patients with biopsy proven single peripheral lung metastases. Twenty-four patients (median age 73 years) with a mean maximum tumor diameter of 2.5 cm (range, 0.8-4.5 cm) were treated over a 6-year period extending from September 2004 to September 2010 and followed for a minimum of 1 year or until death. A mean dose of 52 Gy (range, 45-60 Gy) was delivered to the prescription isodose line in three fractions over a 3-11 day period (mean, 7 days). At a median follow-up of 20 months, the 2-year Kaplan-Meier local control and overall survival rates were 87 and 50%, respectively. CyberKnife with fiducial tracking is an effective treatment for high-risk surgical patients with single small peripheral lung metastases. Trials comparing CyberKnife with metastasectomy for operable patients are necessary to confirm equivalence. © 2012 Snider, Oermann, Chen, Rabin, Suy, Yu, Vahdat, Collins, Banovac, Anderson and Collins.

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Snider, J. W., Oermann, E. K., Chen, V., Rabin, J., Suy, S., Yu, X., … Collins, B. T. (2012). CyberKnife with tumor tracking: An effective treatment for high-risk surgical patients with single peripheral lung metastases. Frontiers in Oncology, 2 JUN. https://doi.org/10.3389/fonc.2012.00063

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