GNAQ/11 mutations in uveal melanoma: Is YAP the key to targeted therapy?

Abstract

GNAQ and GNA11 are frequently mutated in uveal melanoma, but they remain difficult therapeutic targets. In this issue of Cancer Cell, Feng and colleagues and Yu and colleagues demonstrate that the oncogenic activity of mutant GNAQ/11 is mediated at least in part through YAP, potentially uncovering a new therapeutic strategy. © 2014 Elsevier Inc.