The Cellular and Molecular Biology of Aging

Abstract

Aging is characterized as a complex biological process, marked by a progressive diminution in physiological capacities and an escalated susceptibility to diverse diseases. This trajectory detrimentally affects individual well-being and exerts considerable strain on healthcare frameworks and economic stability. Effective methods to prevent and reverse aging have been explored in academic research and clinical settings for a long time. However, the long-term effectiveness and safety of anti-aging measures still need to be further verified. This article provides insight into specific biological mechanisms associated with aging, such as genomic instability, telomere dysfunction, epigenetic modifications, and mitochondrial dysfunction. In addition, the complex role of autophagic activity, senescence-associated secretory phenotypes and epigenetics with aging is also discussed, emphasizing the importance of understanding these processes for aging interventions.