Cohesin: It?s Functions and Relevance to Cancer

Abstract

Oncogene mutations, inactivation of tumor suppressor genes and chromosome instability are classic features of cancer. The sister chromatid cohesion complex, known as cohesin, is conserved among eukaryotes and is essential for efficient chromosome segregation. In this review, we focus on the key findings about cohesin biology and how cohesin misregulation can be deleterious.