Osobennosti immunnogo otveta limfoidnykh organov na gribkovyǐ i stafilokokkovyǐ antigeny v éksperimente.

Abstract

Increased proliferative and functional activities of the lymphoid organs and a high mitotic activity of the lymphocyte blast forms were recorded by autohistoradiography (3H thymidine and 35S-labeled sulfate) in 60 guinea pigs in acute experiments (a challenge with staphylococcal or fungal antigen). Degeneration of the lymphoid tissue and substitution of the lymphoid tissue with fatty tissue were observed in a chronic experiment. Discoordination of the immune response consisted in depression of the T-component, with the B-component retaining high activity; these shifts were the most manifest after challenge with fungal antigen.