Spectral Correlations and Antimicrobial Activities of Some (E)-N-Benzylidenepyridin-2-Amines

Abstract

A series of aryl imines have been synthesized by Fly-ash: PTS catalyzed microwave assisted oxidative coupling of amines and aldehydes under solvent-free conditions. The yield of the imines has been found to be more than 90%. The purity of all imines has been checked using their physical constants and spectral data as published earlier in literature. The UV λ max C=N(nm), infrared νC=N(cm -1 ), NMR δ(ppm) of CH=N and C=N spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The antimicrobial activities of all imines have been studied using Bauer-Kirby method.