Branching cascades: A concise synthetic strategy targeting diverse and complex molecular frameworks

Abstract

Touch 'n' transform: A synthetic strategy based on cascade or domino reaction sequences enabled the simultaneous incorporation of skeletal diversity and molecular complexity in focused compound collections. Thus, the treatment of a common multifunctionalized substrate with various cascade-triggering molecules (see picture) generated a wide range of both natural product related and unprecedented molecular frameworks. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.