Effect of Hydrophilic-Lipophilic Balance (HLB) Values of Surfactant Mixtures on the Physicochemical Properties of Emulsifiable Concentrate Formulations of Difenoconazole

Abstract

This study was designed to investigate the effect of hydrophilic-lipophilic balance (HLB) values of different surfactant mixtures on the physicochemical properties of emulsifiable concentrate formulations of difenoconazole. Physical tests of emulsion characteristics and storage stability studies were performed for the different samples to predict the stability of these formulations. Different parameters such as active ingredient content, pH, refractive index, surface tension, viscosity, flash point, persistent foam was determined for the prepared samples. The results showed that difenoconazole could be formulated as a stable emulsifiable concentrate by using a mixture of surfactants at HLB values 9.7, 11.9, 12.5 and 13.1. The storage stability test showed that the decomposition rate of the active ingredient content of difenoconazole in different stable formulations was within the acceptable limits of FAO Specifications. The physical and chemical properties of the stable formulations fulfilled the requirements of EC formulation.