Circulating retinol-binding protein 4 and subclinical cardiovascular disease in the elderly

Abstract

OBJECTIVE - We evaluated associations of serum retinol-binding protein 4 (RBP4) with subclinical cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS - Subclinical CVD was measured with echocardiography, carotid artery ultrasound, brachial artery ultrasound, and invasive forearm endothelial vasoreactivity in 1,008 70-year-old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. RESULTS - In analyses adjusted for multiple CVD risk factors, we observed inverse associations of RBP4 with carotid artery intima-media (β- 0.39, 95% CI -0.55to -0.22)and plaque (J-0.33, 95% CI -0.60 to -0.05) echogenicity (gray scale median). CONCLUSIONS - Circulating RBP4 concentrations were inversely associated with intima-media and plaque echogenicity in carotid arteries. These findings imply that RBP4 could be involved in the development of atherosclerosis. © 2009 by the American Diabetes Association.